Abstract |
At present, little is known about the pathogenesis of acute virus-induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
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Authors | M T Puglielli, J L Browning, A W Brewer, R D Schreiber, W J Shieh, J D Altman, M B Oldstone, S R Zaki, R Ahmed |
Journal | Nature medicine
(Nat Med)
Vol. 5
Issue 12
Pg. 1370-4
(Dec 1999)
ISSN: 1078-8956 [Print] United States |
PMID | 10581078
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibodies, Monoclonal
- LTBR protein, human
- Ltbr protein, mouse
- Lymphotoxin beta Receptor
- Receptors, Tumor Necrosis Factor
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Topics |
- Animals
- Antibodies, Monoclonal
(pharmacology)
- Disease Models, Animal
- Female
- Humans
- Lymphocytic Choriomeningitis
(immunology, pathology, therapy)
- Lymphotoxin beta Receptor
- Male
- Mice
- Mice, Inbred NZB
- Receptors, Tumor Necrosis Factor
(antagonists & inhibitors)
- Respiratory Insufficiency
(immunology, pathology, therapy)
- Shock, Septic
(immunology, pathology, therapy)
- Signal Transduction
- Time Factors
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