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Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway.

Abstract
At present, little is known about the pathogenesis of acute virus-induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
AuthorsM T Puglielli, J L Browning, A W Brewer, R D Schreiber, W J Shieh, J D Altman, M B Oldstone, S R Zaki, R Ahmed
JournalNature medicine (Nat Med) Vol. 5 Issue 12 Pg. 1370-4 (Dec 1999) ISSN: 1078-8956 [Print] United States
PMID10581078 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies, Monoclonal
  • LTBR protein, human
  • Ltbr protein, mouse
  • Lymphotoxin beta Receptor
  • Receptors, Tumor Necrosis Factor
Topics
  • Animals
  • Antibodies, Monoclonal (pharmacology)
  • Disease Models, Animal
  • Female
  • Humans
  • Lymphocytic Choriomeningitis (immunology, pathology, therapy)
  • Lymphotoxin beta Receptor
  • Male
  • Mice
  • Mice, Inbred NZB
  • Receptors, Tumor Necrosis Factor (antagonists & inhibitors)
  • Respiratory Insufficiency (immunology, pathology, therapy)
  • Shock, Septic (immunology, pathology, therapy)
  • Signal Transduction
  • Time Factors

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