HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

DNA vaccination with the serine rich Entamoeba histolytica protein (SREHP) prevents amebic liver abscess in rodent models of disease.

Abstract
Amebiasis remains one of the leading parasitic causes of death worldwide. A vaccine that prevented amebic liver abscess would significantly reduce mortality from this disease. To test the feasibility of a DNA vaccine to prevent amebic liver abscess, we immunized both mice and gerbils with plasmid DNA encoding the serine rich Entamoeba histolytica protein (SREHP). Animals receiving the SREHP DNA vaccine developed both antibody and cell mediated immune responses that recognized amebic trophozoites. A single dose of the SREHP DNA vaccine protected 80% of vaccinated mice and 60% of vaccinated gerbils from developing amebic liver abscess after direct hepatic inoculation of amebic trophozoites. Our study indicates that DNA vaccination with SREHP can provide high levels of protection against amebic liver abscess in animal models of disease.
AuthorsT Zhang, S L Stanley Jr
JournalVaccine (Vaccine) Vol. 18 Issue 9-10 Pg. 868-74 (Dec 10 1999) ISSN: 0264-410X [Print] Netherlands
PMID10580200 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies, Protozoan
  • Membrane Proteins
  • Protozoan Proteins
  • Vaccines, DNA
  • serine-rich protein, Entamoeba histolytica
  • Serine
Topics
  • Animals
  • Antibodies, Protozoan (biosynthesis)
  • Cell Division
  • Disease Models, Animal
  • Entamoeba histolytica
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gerbillinae
  • Immunity, Cellular
  • Liver Abscess, Amebic (prevention & control)
  • Male
  • Membrane Proteins (genetics)
  • Mice
  • Protozoan Proteins (genetics)
  • Serine
  • Vaccines, DNA

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: