Lung surfactant proteins (SP-A and SP-D) in non-adaptive host responses to infection.

Abstract

The lung surfactant proteins A and D (SP-A and SP-D) are collectins composed of C-type lectin domains attached to collagen regions. SP-A and SP-D are mainly found in the surfactant covering the pulmonary epithelial cells, but are also produced by cells lining the gastrointestinal tract. The main role of SP-A and SP-D is to interact directly with carbohydrate on the surface of microbial pathogens, thereby initiating a variety of effector mechanisms. This review focuses on the non-adaptive host responses of SP-A and SP-D to infection. Interaction of SP-A and SP-D with phagocytes is discussed and the structure and function of the putative receptors for SP-A and SP-D is presented. SP-A and SP-D seem to be regulated in a way similar to acute-phase proteins in the course of inflammation and evidence for the involvement of SP-A and SP-D as immunomodulators as well as their role in clearing allergens and modulating effector mechanisms in allergic reactions is discussed.

• Authors: U Holmskov
• Journal: Journal of leukocyte biology (J Leukoc Biol) Vol. 66 Issue 5 Pg. 747-52 (Nov 1999) ISSN: 0741-5400 [Print] United States
• PMID: 10577504 (Publication Type: Journal Article, Review)

Chemical References

• C1QBP protein, human
• Carrier Proteins
• Glycoproteins
• Hyaluronan Receptors
• Membrane Glycoproteins
• Mitochondrial Proteins
• Proteolipids
• Pulmonary Surfactant-Associated Protein A
• Pulmonary Surfactant-Associated Protein D
• Pulmonary Surfactant-Associated Proteins
• Pulmonary Surfactants
• Receptors, Complement
• complement 1q receptor

Topics

• Adaptation, Physiological (immunology)
• Animals
• Carrier Proteins
• Glycoproteins (immunology)
• Humans
• Hyaluronan Receptors
• Hypersensitivity (immunology)
• Infections (immunology)
• Lung (immunology)
• Membrane Glycoproteins
• Mitochondrial Proteins
• Proteolipids (immunology)
• Pulmonary Surfactant-Associated Protein A
• Pulmonary Surfactant-Associated Protein D
• Pulmonary Surfactant-Associated Proteins
• Pulmonary Surfactants (immunology)
• Receptors, Complement (immunology)