Dynamic contrast-enhanced MRI of Implanted VX2 tumors in rabbit muscle: comparison of Gd-DTPA and NMS60.

Abstract

We studied the dynamics of injected contrast enhancement in implanted VX2 tumors in rabbit thigh muscle. We compared two contrast agents Gd-DTPA and NMS60, a novel gadolinium containing trimer of molecular weight 2.1 kd. T1-weighted spin echo images were acquired preinjection and at 5-60 min after i.v. injection of 0.1 mmol/kg of agent. Dynamic T1-weighted SPGR images (1.9 s/image) were acquired during the bolus injection. Male NZW rabbits (n = 13) were implanted with approximately 2 x 10(6) VX2 tumor cells and grew tumors of 28+/-27 mL over 12 to 21 days. NMS60 showed significantly greater peak enhancement in muscle, tumor rim, and core compared to DTPA in both T1-weighted and SPGR images. NMS60 also showed delayed peak enhancement in the dynamic scans (compared to Gd-DTPA) and significantly reduced leakage rate constant into the extravascular space for tumor rim (K21 = 5.1 min(-1) vs. 11.5 min(-1) based on a 2 compartment kinetic model). The intermediate weight contrast agent NMS60 offers greater tumor enhancement than Gd-DTPA and may offer improved regional differentiation on the basis of vascular permeability in tumors.

• Authors: A J de Crespigny, D Howard, H D'Arceuil, H Muller, A T Agoston, S Seri, Y Hashiguchi, C Fujimoto, A Nakatani, M E Moseley
• Journal: Magnetic resonance imaging (Magn Reson Imaging) Vol. 17 Issue 9 Pg. 1297-305 (Nov 1999) ISSN: 0730-725X [Print] Netherlands
• PMID: 10576715 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Contrast Media
• NMS60
• Organometallic Compounds
• Gadolinium DTPA

Topics

• Animals
• Capillary Permeability
• Carcinoma (diagnosis)
• Contrast Media (chemistry)
• Gadolinium DTPA
• Magnetic Resonance Imaging (methods)
• Male
• Muscle Neoplasms (diagnosis)
• Neoplasm Transplantation
• Organometallic Compounds (chemistry)
• Rabbits
• Time Factors