Circadian variation of plasma arginine vasopressin concentration, or arginine vasopressin in enuresis.

Abstract

The objective of these studies was to determine a relationship between primary nocturnal enuresis and arginine vasopressin (AVP) secretion. The first study compared 24-h AVP secretion profiles of enuretic (n = 9) and non-enuretic children (n = 8). Blood samples were collected at 1-h intervals for 24 h. In the second study, nocturnal AVP secretion in group A (n = 40)--with low urinary osmotic pressure (UOP) and large nocturnal urine output (NUO)--was compared with that in group D (n = 11) with normal UOP and small NUO. Plasma AVP levels were measured at 30-min intervals, immediately after falling asleep until 06.00 the following morning. The results of the first study showed that the plasma AVP level was significantly lower (p < 0.05-0.001) in the enuretic group between 23.00 and 04.00. The second study showed that group A had significantly lower AVP levels (p < 0.05-0.001) than group D throughout the night. The mean AVP level during night sleep was 0.64 +/- 0.23 pg/ml in group A and 1.43 +/- 0.66 pg/ml in group D. The results of the first study suggest that decreased nocturnal AVP secretion is a cause of bedwetting. However, the results of the second study suggest that nocturnal enuresis cannot be explained by a decrease in nocturnal AVP secretion alone.

• Authors: T Aikawa, T Kasahara, M Uchiyama
• Journal: Scandinavian journal of urology and nephrology. Supplementum (Scand J Urol Nephrol Suppl) Vol. 202 Pg. 47-9 ( 1999) ISSN: 0300-8886 [Print] England
• PMID: 10573793 (Publication Type: Journal Article)

Chemical References

• Arginine Vasopressin

Topics

• Adolescent
• Arginine Vasopressin (blood)
• Child
• Circadian Rhythm (physiology)
• Enuresis (physiopathology)
• Female
• Humans
• Male
• Polysomnography
• Reference Values
• Sleep Stages (physiology)
• Urodynamics (physiology)
• Water-Electrolyte Balance (physiology)