The effects of trazodone on sleep disturbances induced by brofaromine.

Abstract

The effects of trazodone on subjective and objective sleep parameters were compared to those of placebo in a double-blind design in seven patients who developed insomnia during treatment with the selective and reversible MAO-A inhibitor, brofaromine. Trazodone significantly increased deep sleep and altered the architecture of sleep in these patients. Subjectively, patients reported a better and deeper sleep. No negative interactions between brofaromine and trazodone were observed and side-effects were minimal. A low dose of trazodone may be a safe and effective agent in the treatment of MAO-I induced insomnia.

• Authors: P M Haffmans, M S Vos
• Journal: European psychiatry : the journal of the Association of European Psychiatrists (Eur Psychiatry) Vol. 14 Issue 3 Pg. 167-71 (Jun 1999) ISSN: 0924-9338 [Print] England
• PMID: 10572343 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Monoamine Oxidase Inhibitors
• Piperidines
• Serotonin Uptake Inhibitors
• brofaromine
• Trazodone

Topics

• Dose-Response Relationship, Drug
• Double-Blind Method
• Electroencephalography
• Follow-Up Studies
• Humans
• Monoamine Oxidase Inhibitors (adverse effects)
• Piperidines (adverse effects)
• Selective Serotonin Reuptake Inhibitors (therapeutic use)
• Sleep Initiation and Maintenance Disorders (chemically induced, drug therapy)
• Sleep, REM (drug effects)
• Trazodone (pharmacology, therapeutic use)
• Wakefulness (drug effects)