Central regulation of sympathetic neuron development.

Abstract

The sixth lumbar (L-6) ganglion has been used to study the central regulation of peripheral sympathetic neuron development. During post-natal ontogeny, tyrosine hydroxylase [tyrosine 3-monooxygenase, L-tyrosine, tetrahydropteridine: oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] activity increased 60-fold, while total protein rose 10-fold in the ganglion. Transection of the spinal cord at the fifth thoracic (T-5) segment in neonatal rats prevented the normal developmental increase in tyrosine hydroxylase activity of the L-6 ganglion. However, spinal transection did not alter the ontogeny of tyrosine hydroxylase in the superior cervical ganglion, which derives its innervation from spinal segments rostral to the surgical lesion. Thus, spinal transection interfered with the maturation of sympathetic neurons distal to, but not proximal to, the lesion. The effect of transection on the L-6 ganglion persisted for at least one month, the longest time tested. Our observations suggest that trans-synaptic regulation of adrenergic maturation in the periphery is governed by suprasegmental mechanisms in the central nervous system.

• Authors: I B Black, E M Bloom, R W Hamill
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 73 Issue 10 Pg. 3575-8 (Oct 1976) ISSN: 0027-8424 [Print] United States
• PMID: 10572 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Nerve Tissue Proteins
• Tyrosine 3-Monooxygenase

Topics

• Animals
• Central Nervous System (physiology)
• Cordotomy
• Ganglia, Autonomic (enzymology, growth & development)
• Nerve Tissue Proteins (biosynthesis)
• Neural Pathways (physiology)
• Rats
• Time Factors
• Tyrosine 3-Monooxygenase (biosynthesis)