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Gammadelta T cell response induced by vaginal Herpes simplex 2 infection.

Abstract
The purpose of the present studies was to determine whether acute vaginal infection with Herpes virus 2 altered the vaginal population of gammadelta T cells, and whether gammadelta T cells influenced the vaginal clearance of HSV-2. BALB/c mice were infected intravaginally with the progressively lethal wild type 333 strain, or the non-lethal thymidine kinase deficient (deltaTK- -HSV-2) mutant strain of HSV-2 virus. Changes in vaginal T cell composition were examined by FACS analysis 4 days after infection. Clearance of vaginal deltaTK- -HSV-2 infection was compared between mice with normal gammadelta T cell populations (BALB/c) and transgenic mice in which all the gammadelta T cells express a receptor that is specific for the b allotype of MHC class Ib T10 antigen (G8/BALB/c). In HSV-2 infected BALB/c mice, but not G8/BALB/c, a subset of gammadelta T cells that express a Vgamma2 TCR accumulated in the vaginal mucosa by the fourth day after infection. Unexpectedly, we found that gammadelta TCR transgenic mice exhibited a more rapid clearance of the virus than control mice (P < 0.05). These findings argue against the hypothesis that the normal populations of vaginal intraepithelial gammadelta T cells play a direct role in the elimination of virally infected epithelial cells.
AuthorsE Rakasz, A Mueller, S Perlman, R G Lynch
JournalImmunology letters (Immunol Lett) Vol. 70 Issue 2 Pg. 89-93 (Nov 01 1999) ISSN: 0165-2478 [Print] Netherlands
PMID10569697 (Publication Type: Journal Article)
Chemical References
  • Receptors, Antigen, T-Cell, gamma-delta
Topics
  • Animals
  • Female
  • Flow Cytometry
  • Herpes Genitalis (immunology, virology)
  • Herpesvirus 2, Human (immunology, physiology)
  • Mice
  • Mice, Inbred BALB C
  • Receptors, Antigen, T-Cell, gamma-delta (metabolism)
  • T-Lymphocytes (immunology)
  • Vagina (immunology, virology)
  • Virus Replication

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