Abstract | PURPOSE: MATERIALS AND METHODS: We retrospectively reviewed the records of 58 patients in whom metastatic renal cell carcinoma was diagnosed at our hospital between 1986 and 1997. Three patients were excluded from study because they were judged to be poor candidates for surgery due to poor performance status. Of the remaining 55 patients 34 consented to cytoreductive surgery of the primary tumor and 21 did not. All except 1 patient were treated with interferon therapy. We evaluated the association of pretreatment serum C-reactive protein and the effect of surgery. RESULTS: We noted no significant difference in age at diagnosis, pretreatment serum immunosuppressive acidic protein, site of metastasis or performance status in 34 patients who underwent cytoreductive surgery and 21 who did not. Of the 21 patients in whom pretreatment serum C-reactive protein was within normal limits (less than 1.0 ng./ml.) no significant difference in disease specific survival was observed in those who did and did not undergo surgery (p = 0.4133). On the other hand, of 34 patients in whom pretreatment serum C-reactive protein was elevated (1.0 ng./ml. or greater) the prognosis was significantly better in those who did versus those who did not undergo surgery (p = 0.0054). Particularly the prognosis in patients in whom postoperative nadir C-reactive protein decreased to within normal limits was markedly better than in those in whom it remained elevated (p = 0.0025). CONCLUSIONS:
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Authors | K Fujikawa, Y Matsui, H Oka, S Fukuzawa, H Takeuchi |
Journal | The Journal of urology
(J Urol)
Vol. 162
Issue 6
Pg. 1934-7
(Dec 1999)
ISSN: 0022-5347 [Print] United States |
PMID | 10569541
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- C-Reactive Protein
(analysis)
- Carcinoma, Renal Cell
(blood, mortality, secondary, surgery)
- Female
- Humans
- Kidney Neoplasms
(blood, mortality, surgery)
- Male
- Middle Aged
- Retrospective Studies
- Survival Rate
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