Pain relief of oral ulcer by dibucaine-film.

Abstract

A water-soluble three-layered oral mucosa-adhesive film made from hydroxypropyl cellulose containing dibucaine (0.25 mg of drug/cm(2)) was designed for alleviation of severe pain due to oral ulcers, caused by chemotherapy and/or radiotherapy. We report two patients with constant severe pain ulcers treated with the dibucaine film. Patients were asked to record the time that pain was relieved while chewing following first application of the film. Pain relief lasted for 2-5 h after application of the dibucaine film.

• Authors: Keiko Yamamura, Toshihisa Yotsuyanagi, Tomomitsu Okamoto, Toshitaka Nabeshima
• Journal: Pain (Pain) Vol. 83 Issue 3 Pg. 625-626 (Dec 1999) ISSN: 0304-3959 [Print] United States
• PMID: 10568871 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adhesives
• Anesthetics, Local
• Cellulose
• hydroxypropylcellulose
• Dibucaine

Topics

• Adhesives (administration & dosage)
• Administration, Topical
• Adult
• Aged
• Aged, 80 and over
• Anesthetics, Local (administration & dosage)
• Cellulose (administration & dosage, analogs & derivatives)
• Dibucaine (administration & dosage)
• Female
• Humans
• Mouth Mucosa (drug effects)
• Oral Ulcer (drug therapy)