Abstract |
Fibroblast growth factors (FGFs) are powerful angiogenic polypeptides that are involved in the autocrine growth stimulation of gliomas. We report here that addition to glioma cell cultures of 1,3,6-naphthalenetrisulfonate (NTS), an inhibitor of the mitogenic activity of FGFs, significantly enhanced apoptosis, as assessed by terminal deoxynucleotidyl transferase (TdT) assay. The pro-apoptotic effect of NTS was time-dependent. These findings suggest that FGF may play a pivotal role in the survival of glioma cells, and support a clinical interest of NTS as a leading compound for the development of new antitumorals.
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Authors | P Cuevas, D Reimers, D Diaz, R M Lozano, G Giménez-Gallego |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 275
Issue 2
Pg. 149-51
(Nov 12 1999)
ISSN: 0304-3940 [Print] Ireland |
PMID | 10568521
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 1,3,6-naphthalenetrisulfonate
- Naphthalenesulfonates
- Fibroblast Growth Factors
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Topics |
- Animals
- Apoptosis
(drug effects)
- Fibroblast Growth Factors
(antagonists & inhibitors)
- Glioma
(drug therapy, pathology)
- In Situ Nick-End Labeling
- Naphthalenesulfonates
(pharmacology)
- Rats
- Tumor Cells, Cultured
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