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Apoptosis of glioma cells induced by the fibroblast growth factor inhibitor 1,3,6-naphthalenetrisulfonate.

Abstract
Fibroblast growth factors (FGFs) are powerful angiogenic polypeptides that are involved in the autocrine growth stimulation of gliomas. We report here that addition to glioma cell cultures of 1,3,6-naphthalenetrisulfonate (NTS), an inhibitor of the mitogenic activity of FGFs, significantly enhanced apoptosis, as assessed by terminal deoxynucleotidyl transferase (TdT) assay. The pro-apoptotic effect of NTS was time-dependent. These findings suggest that FGF may play a pivotal role in the survival of glioma cells, and support a clinical interest of NTS as a leading compound for the development of new antitumorals.
AuthorsP Cuevas, D Reimers, D Diaz, R M Lozano, G Giménez-Gallego
JournalNeuroscience letters (Neurosci Lett) Vol. 275 Issue 2 Pg. 149-51 (Nov 12 1999) ISSN: 0304-3940 [Print] Ireland
PMID10568521 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 1,3,6-naphthalenetrisulfonate
  • Naphthalenesulfonates
  • Fibroblast Growth Factors
Topics
  • Animals
  • Apoptosis (drug effects)
  • Fibroblast Growth Factors (antagonists & inhibitors)
  • Glioma (drug therapy, pathology)
  • In Situ Nick-End Labeling
  • Naphthalenesulfonates (pharmacology)
  • Rats
  • Tumor Cells, Cultured

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