[Comparison of the reactivating effect of BI-6, a new asymmetrical bispyridinium oxime, with oxime HI-6 and obidoxime on soman-inhibited acetylcholinesterase in the diaphragm and various parts of the brain in rats].

Abstract

BACKGROUND:

Acute poisoning with the highly toxic organophosphorus agent, soman, is not treated satisfactorily even by the most modern antidotes.

METHODS AND RESULTS:

In experiments on rats, the reactivating effect of a new asymmetric bispyridinium oxime BI-6 was compared with widely used oximes HI-6 and obidoxime by investigating the changes of soman-inhibited acetylcholinesterase activity in the diaphragm and various parts of the brain in rats up to three hours following soman challenge. Our findings confirm that the new oxime BI-6 is a more effective reactivator of soman-inhibited acetylcholinesterase than obidoxime but not as effective as the oxime HI-6 especially in the peripheral compartment.

CONCLUSIONS:

The new oxime BI-6 is not as effective as HI-6 which seems to have definite advantages over other oximes in the treatment of soman poisoning.

• Authors: J Kassa, J Bajgar
• Journal: Casopis lekaru ceskych (Cas Lek Cesk) Vol. 138 Issue 17 Pg. 532-5 (Aug 30 1999) ISSN: 0008-7335 [Print] Czech Republic
• Vernacular Title: Srovnání reaktivacní úcinnosti nového asymetrického bispyridiniového oximu BI-6 s oximem HI-6 a obidoximem vůci somanem inhibované acetylcholinesteráze v bránici a různých cástech mozku potkana.
• PMID: 10566233 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antidotes
• BI 6
• Chemical Warfare Agents
• Cholinesterase Inhibitors
• Cholinesterase Reactivators
• Oximes
• Pyridinium Compounds
• Obidoxime Chloride
• Soman
• Acetylcholinesterase
• asoxime chloride

Topics

• Acetylcholinesterase (metabolism)
• Animals
• Antidotes (pharmacology)
• Brain (enzymology)
• Chemical Warfare Agents (toxicity)
• Cholinesterase Inhibitors (toxicity)
• Cholinesterase Reactivators (pharmacology)
• Diaphragm (enzymology)
• Male
• Obidoxime Chloride (pharmacology)
• Oximes (pharmacology)
• Pyridinium Compounds (pharmacology)
• Rats
• Rats, Wistar
• Soman (toxicity)