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Ondansetron treatment in patients with Tourette's syndrome.

Abstract
Ondansetron, a selective 5-HT3 antagonist, may lower mesolimbic dopaminergic hyperactivity. The present open-label pilot study evaluated the effect of ondansetron in Tourette's syndrome. Six Tourette's syndrome men aged 14-48 years resistant to haloperidol participated in the study. Assessments included the Yale Global Tic Severity Scale (YGTSS), Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and Tourette's syndrome-Clinical Global Impression (TS-CGI) scale. The maximal ondansetron dosage (8-16 mg per day) was given for 3 weeks. Ondansetron treatment was associated with a significant decrease in the severity of tics. Two patients showed a definite response (score improvement of 40% or more), and two showed a probable response (> 25%). Two patients did not improve. Side-effects were transient and included abdominal pain (n = 5) and constipation (n = 2). Ondansetron may possess anti-tic effects in some Tourette's syndrome patients.
AuthorsP Toren, N Laor, D J Cohen, L Wolmer, A Weizman
JournalInternational clinical psychopharmacology (Int Clin Psychopharmacol) Vol. 14 Issue 6 Pg. 373-6 (Nov 1999) ISSN: 0268-1315 [Print] ENGLAND
PMID10565805 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Serotonin Antagonists
  • Ondansetron
Topics
  • Adolescent
  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder (complications, drug therapy, psychology)
  • Ondansetron (adverse effects, therapeutic use)
  • Pilot Projects
  • Psychiatric Status Rating Scales
  • Serotonin Antagonists (adverse effects, therapeutic use)
  • Tourette Syndrome (complications, drug therapy, psychology)

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