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[A multicenter early phase II study of high-dose chemotherapy with autologous peripheral blood stem cell transplantation for treatment of intermediate-grade non-Hodgkin's lymphoma. Japan Blood Cell Transplantation Study Group].

Abstract
We conducted a multicenter early phase II study to evaluate the feasibility and therapeutic efficacy of high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto-PBSCT) for the treatment of intermediate grade non-Hodgkin's lymphoma (IG-NHL). High-dose etoposide or cyclophosphamide followed by G-CSF was used for PBSC mobilization, and a sufficient number of CD34+ cells (> 1 x 10(6)/kg) were collected. Out of 81 enrolled patients, 50 received high-dose chemotherapy with auto-PBSCT; Hematologic recovery after transplantation was rapid. The incidence of grade III/IV toxicity (Bearman) was about 6%; treatment-related mortality was 6% (3/50). The Disease-free survival rate for the patients in complete remission who received high-dose chemotherapy with auto-PBSCT was better than that for the patients who were treated with conventional chemotherapy (57% vs 35%). These preliminary results indicated that high-dose chemotherapy with auto-PBSCT is feasible and effective. A prospective randomized phase III clinical trial will be required to assess the efficacy of high-dose chemotherapy with auto-PBSCT as a post-remission therapy for IG-NHL.
AuthorsT Chou, T Ishiguro, K Imajo, F Kawano, H Gondo, M Kasai, M Masuda, M Koike, C Shimazaki, M Hara, K Shinagawa, M Ogawa, F Takaku, M Harada
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 40 Issue 10 Pg. 1058-67 (Oct 1999) ISSN: 0485-1439 [Print] JAPAN
PMID10565222 (Publication Type: Clinical Trial, Clinical Trial, Phase II, English Abstract, Journal Article, Multicenter Study)
Topics
  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Chemotherapy, Adjuvant
  • Disease-Free Survival
  • Female
  • Hematopoietic Stem Cell Transplantation (adverse effects)
  • Humans
  • Lymphoma, Non-Hodgkin (therapy)
  • Male
  • Middle Aged
  • Transplantation, Autologous
  • Treatment Outcome

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