Abstract | STUDY DESIGN: An experimental study of changes in the microvasculature of the injured spinal cord that occur with methylprednisolone and vitamin E treatment. OBJECTIVE: SUMMARY OF BACKGROUND DATA:
Silicon rubber microangiography provided an excellent three-dimensional method for defining the distribution of vasculature in untreated and treated rats after injury. Therefore, silicone rubber microangiography was helpful for elucidating the pathophysiology of posttraumatic ischemia and hemorrhages in the spinal cord. METHODS: In this study, 30 adult rats underwent laminectomy between C7 and T2 followed by extradural spinal cord clipping to produce the compression injury. A control group of 10 rats was left untreated, and 10 rats were treated with methylprednisolone (30 mg/kg bolus and 5.4 mg per hour for 24 hours). Another 10 rats were treated with methylprednisolone and vitamin E (100 U/kg per day). The animals were killed 4, 24, or 48 hours after injury. Silicon rubber microangiography was performed after injury to assess the vasculature of rats' spinal cord. Spinal cord injury causes rapid elevation of noradrenalin, adrenaline, and dopamine. Venous blood samples were taken from all animals before the silicone rubber microangiography was performed. RESULTS: CONCLUSIONS: Findings showed that the addition of vitamin E to the methylprednisolone treatment made no difference in the extent of the ischemic area as compared with methylprednisolone treatment given alone. However, the statistical analysis did not show a significant difference between the treated and untreated groups.
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Authors | M Daneyemez |
Journal | Spine
(Spine (Phila Pa 1976))
Vol. 24
Issue 21
Pg. 2201-5
(Nov 01 1999)
ISSN: 0362-2436 [Print] United States |
PMID | 10562984
(Publication Type: Journal Article)
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Chemical References |
- Silicone Elastomers
- Vitamin E
- Methylprednisolone
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Topics |
- Angiography
- Animals
- Methylprednisolone
(therapeutic use)
- Microcirculation
(drug effects, physiopathology)
- Rats
- Silicone Elastomers
- Spinal Cord
(diagnostic imaging, drug effects, surgery)
- Spinal Cord Injuries
(drug therapy, physiopathology)
- Time Factors
- Vitamin E
(therapeutic use)
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