Abstract | BACKGROUND: METHODS:
Formalin fixed tumor biopsy samples from 34 patients with HNSCC of the oral cavity, oropharynx, or hypopharynx were analyzed for the presence of cathepsin-D by immunohistochemistry (1:8000, Calbiochem, Cambridge, MA). Tumors were considered positive if >50% of cells showed strong cytoplasmic staining. RESULTS: All patients had T1 or T2 lesions ranging in size from 1-4 cm and 19 (56%) had cervical metastasis. Eight (24%) were well differentiated and 26 (76%) were moderately or poorly differentiated. Thirteen tumors (38%) had high cathepsin-D expression that was strongly associated with cervical lymph node metastasis (p = 0.008). When adjusted for tumor stage and grade, cathepsin-D positivity was nearly twice as likely to be associated with node metastasis (p = 0.011). CONCLUSIONS:
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Authors | R Gandour-Edwards, B Trock, P J Donald |
Journal | Head & neck
(Head Neck)
Vol. 21
Issue 8
Pg. 718-22
(Dec 1999)
ISSN: 1043-3074 [Print] United States |
PMID | 10562684
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 1999 John Wiley & Sons, Inc. Head Neck 21: 718-722, 1999. |
Chemical References |
- Biomarkers, Tumor
- Cathepsin D
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Topics |
- Biomarkers, Tumor
(analysis)
- Carcinoma, Squamous Cell
(chemistry, pathology)
- Cathepsin D
(analysis)
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Mouth Neoplasms
(chemistry, pathology)
- Neck
- Pharyngeal Neoplasms
(chemistry, pathology)
- Predictive Value of Tests
- Prognosis
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