A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against Bacillus species.

Abstract	Two nontoxic, antimicrobial nanoemulsions, BCTP and BCTP 401, have been developed. These emulsions are composed of detergents and oils in 80% water. BCTP diluted up to 1:1000 inactivated>90% of Bacillus anthracis spores in 4 h and was also sporicidal against three other Bacillus species. This sporicidal activity is due to disruption of the spore coat after initiation of germination without complete outgrowth. BCTP 401 diluted 1:1000 had greater activity than BCTP against Bacillus spores and had an onset of action of <30 min. Mixing BCTP or BCTP 401 with Bacillus cereus prior to subcutaneous injection in mice reduced the resulting skin lesion by 99%. Wound irrigation with BCTP 1 h after spore inoculation yielded a 98% reduction in skin lesion size, and mortality was reduced 3-fold. These nanoemulsion formulas are stable, easily dispersed, nonirritant, and nontoxic compared with other available sporicidal agents.
Authors	T Hamouda, M M Hayes, Z Cao, R Tonda, K Johnson, D C Wright, J Brisker, J R Baker Jr
Journal	The Journal of infectious diseases (J Infect Dis) Vol. 180 Issue 6 Pg. 1939-49 (Dec 1999) ISSN: 0022-1899 [Print] United States
PMID	10558951 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Anti-Bacterial Agents BCTP 401 nanoemulsion BCTP nanoemulsion Emulsions Glycerides Organophosphates Polysorbates Surface-Active Agents Soybean Oil Octoxynol
Topics	Animals Anti-Bacterial Agents (pharmacology, therapeutic use, toxicity) Bacillaceae Infections (drug therapy) Bacillus (drug effects, physiology) Bacillus cereus (drug effects) Colony Count, Microbial Disease Models, Animal Emulsions Glycerides (pharmacology, therapeutic use, toxicity) Humans Mice Microscopy, Electron Octoxynol (pharmacology, therapeutic use, toxicity) Organophosphates (pharmacology, therapeutic use, toxicity) Polysorbates (pharmacology, therapeutic use, toxicity) Soybean Oil (pharmacology, therapeutic use, toxicity) Spores, Bacterial (drug effects) Surface-Active Agents (pharmacology, therapeutic use, toxicity) Wound Infection (drug therapy, microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!