Abstract | BACKGROUND: Lymph node enlargement in patients with eosinophilic fasciitis is a rare occurrence and its clinical significance is unknown. METHODS: The literature and authors' registries were searched for eosinophilic fasciitis associated with lymphadenopathy. Clinical data, time sequence of appearance of either disorder, and pathological diagnoses were analyzed. RESULTS: CONCLUSIONS:
Eosinophilic fasciitis is rarely associated with clinically significant lymph node enlargement. Subcutaneous induration preceding the lymphadenopathy by 6 months or more, especially in elderly patients, suggests an underlying lymphoma. A favorable response of the subcutaneous induration to prednisone treatment does not exclude the diagnosis of lymphoma; therefore, it does not supersede the need of a pathological evaluation. A lymph node biopsy is mandatory in all cases.
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Authors | J E Naschitz, I Misselevich, I Rosner, D Yeshurun, P Weiner, M Amar, L Amato, M L Ciompi, J H Boss |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 318
Issue 5
Pg. 343-9
(Nov 1999)
ISSN: 0002-9629 [Print] United States |
PMID | 10555099
(Publication Type: Case Reports, Journal Article, Review)
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Topics |
- Adolescent
- Adult
- Aged
- Eosinophils
- Fasciitis
(complications, pathology)
- Female
- Humans
- Lymphatic Diseases
(etiology, pathology)
- Lymphoma
(complications, diagnosis, pathology)
- Male
- Middle Aged
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