Iron tissue storage and hemoglobin levels of deficient rats repleted with iron bound to the caseinophosphopeptide 1-25 of beta-casein.

Abstract

Caseinophosphopeptides (CPP) issued from enzyme digestion of caseins bind cations and keep them soluble in the digestive tract. They could be used as ligands to improve iron (Fe) bioavailability. Fe-deficient young rats were repleted with Fe (40 or 200 mg/kg of diet) bound either to the beta-CN (1-25) of beta-casein or to whole beta-casein or as FeSO(4). A control pair-fed group was given 200 mg of Fe (FeSO(4))/kg of diet for 6 weeks. After repletion, hemoglobin concentration of the control group was reached only by the ) animals fed 200 mg of Fe/kg; beta-CN (1-25) bound Fe (40 and 200 mg) produced higher Fe liver and spleen stores than FeSO(4). Binding Fe to the whole, nonhydrolyzed beta-casein gave results intermediate between the other experimental groups. Binding Fe to phosphoserine residues of low molecular weight CPP improved its ability to cure anemia and to restore iron tissue stores, as compared to Fe bound to the whole casein and to inorganic salts.

• Authors: N Aît-Oukhatar, S Bouhallab, P Arhan, J L Maubois, M Drosdowsky, D Bouglé
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 47 Issue 7 Pg. 2786-90 (Jul 1999) ISSN: 0021-8561 [Print] United States
• PMID: 10552566 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Caseins
• Hemoglobins
• Peptide Fragments
• caseinophosphopeptide 1-25
• Iron

Topics

• Amino Acid Sequence
• Animals
• Caseins (chemistry, metabolism)
• Hemoglobins (metabolism)
• Iron (administration & dosage, metabolism)
• Liver (metabolism)
• Male
• Molecular Sequence Data
• Peptide Fragments (metabolism)
• Protein Binding
• Rats
• Rats, Sprague-Dawley
• Spleen (metabolism)