Abstract | BACKGROUND:
Cholinergic agents reduce allodynia after nerve injury in animals and may be useful in the treatment of neuropathic pain. Intrathecally administered neostigmine and neuronal nicotinic agonists are more potent in female than in male rats against acute thermal noxious stimuli. The purpose of this study was to determine whether there is also a sex difference in the antiallodynic effects of intrathecal cholinomimetic agents in two models of allodynia and to test their pharmacologic mechanisms. METHODS: RESULTS: CONCLUSIONS: These data demonstrate a sex difference of intrathecal neostigmine after nerve injury-induced allodynia similar to that observed in normal animals that received acute noxious thermal stimulation. However, this sex difference is not universal to all pain models because it was not present after intradermal capsaicin injection, nor is its interaction with spinal noradrenergic mechanisms consistent in all models.
|
Authors | P M Lavand'homme, J C Eisenach |
Journal | Anesthesiology
(Anesthesiology)
Vol. 91
Issue 5
Pg. 1455-61
(Nov 1999)
ISSN: 0003-3022 [Print] United States |
PMID | 10551598
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Analgesics
- Cholinergic Agents
- Muscarinic Agonists
- Muscarinic Antagonists
- Nicotinic Agonists
- Nicotinic Antagonists
- Neostigmine
- Capsaicin
|
Topics |
- Analgesics
(administration & dosage, pharmacology)
- Animals
- Capsaicin
(toxicity)
- Cholinergic Agents
(administration & dosage, pharmacology)
- Female
- Injections, Spinal
- Ligation
- Male
- Muscarinic Agonists
(administration & dosage, pharmacology)
- Muscarinic Antagonists
(administration & dosage, pharmacology)
- Neostigmine
(administration & dosage, pharmacology)
- Nicotinic Agonists
(administration & dosage, pharmacology)
- Nicotinic Antagonists
(administration & dosage, pharmacology)
- Pain
(chemically induced, drug therapy)
- Pain Measurement
- Rats
- Rats, Sprague-Dawley
- Sex Factors
- Spinal Nerves
(physiology)
|