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Effects of environmental estrogens on tumor necrosis factor alpha-mediated apoptosis in MCF-7 cells.

Abstract
Environmental estrogens represent a class of compounds which have been shown to mimic the effects or activity of the naturally occurring ovarian hormone 17beta-estradiol. Given the role of 17beta-estradiol in cell survival in a number of systems, we wished to determine if environmental estrogens protect MCF-7 cells from apoptosis. Here we demonstrate that the organochlorine pesticides o, p' DDT and alachlor, like 17beta-estradiol, have the ability to suppress tumor necrosis factor alpha (TNF)-induced apoptosis in estrogen receptor (ER)-positive MCF-7 breast carcinoma cells. These compounds, however, did not affect TNF-induced apoptosis of the ER-negative MDA-MB-231 cell line. The ability of these compounds to suppress apoptosis in MCF-7 cells was correlated with an ER-dependent increase in Bcl-2 expression. Taken together these results demonstrate that estrogenic organochlorine pesticides like o, p' DDT and alachlor may partially mimic the primary endogenous estrogen, 17beta-estradiol, and function to suppress apoptosis in ER-responsive cells.
AuthorsM E Burow, Y Tang, B M Collins-Burow, S Krajewski, J C Reed, J A McLachlan, B S Beckman
JournalCarcinogenesis (Carcinogenesis) Vol. 20 Issue 11 Pg. 2057-61 (Nov 1999) ISSN: 0143-3334 [Print] England
PMID10545406 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Estrogens, Non-Steroidal
  • Receptors, Estrogen
  • Tumor Necrosis Factor-alpha
  • Xenobiotics
Topics
  • Apoptosis (drug effects)
  • Breast Neoplasms (metabolism, pathology)
  • Estrogens, Non-Steroidal (pharmacology)
  • Humans
  • Receptors, Estrogen (metabolism)
  • Tumor Cells, Cultured
  • Tumor Necrosis Factor-alpha (pharmacology)
  • Xenobiotics (pharmacology)

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