Abstract |
Environmental estrogens represent a class of compounds which have been shown to mimic the effects or activity of the naturally occurring ovarian hormone 17beta-estradiol. Given the role of 17beta-estradiol in cell survival in a number of systems, we wished to determine if environmental estrogens protect MCF-7 cells from apoptosis. Here we demonstrate that the organochlorine pesticides o, p' DDT and alachlor, like 17beta-estradiol, have the ability to suppress tumor necrosis factor alpha (TNF)-induced apoptosis in estrogen receptor (ER)-positive MCF-7 breast carcinoma cells. These compounds, however, did not affect TNF-induced apoptosis of the ER-negative MDA-MB-231 cell line. The ability of these compounds to suppress apoptosis in MCF-7 cells was correlated with an ER-dependent increase in Bcl-2 expression. Taken together these results demonstrate that estrogenic organochlorine pesticides like o, p' DDT and alachlor may partially mimic the primary endogenous estrogen, 17beta-estradiol, and function to suppress apoptosis in ER-responsive cells.
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Authors | M E Burow, Y Tang, B M Collins-Burow, S Krajewski, J C Reed, J A McLachlan, B S Beckman |
Journal | Carcinogenesis
(Carcinogenesis)
Vol. 20
Issue 11
Pg. 2057-61
(Nov 1999)
ISSN: 0143-3334 [Print] England |
PMID | 10545406
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Estrogens, Non-Steroidal
- Receptors, Estrogen
- Tumor Necrosis Factor-alpha
- Xenobiotics
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Topics |
- Apoptosis
(drug effects)
- Breast Neoplasms
(metabolism, pathology)
- Estrogens, Non-Steroidal
(pharmacology)
- Humans
- Receptors, Estrogen
(metabolism)
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha
(pharmacology)
- Xenobiotics
(pharmacology)
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