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[Ticlopidine-induced lymphocytic colitis].

Abstract
Lymphocytic colitis is a clinico-pathological syndrome characterized by chronic diarrhea, normal endoscopy, diffuse colonic mucosal inflammatory changes. Collagenous colitis is defined by a thickening of the collagen plate. The etiology is unknown but immune disorders have been frequently associated with it and it has been linked with the taking of certain drugs such as nonsteroïd anti-inflammatory drugs or veinotonics. We are reporting a case of microscopic colitis associating both lymphocytic and collagenous colitis, wich induced chronic diarrhea in a 65-year-old man. It appeared after he had taken ticlopidine. Diarrhea stopped after he had discontinuated ticlopidine, and recurred after he resumed taking the drug. Histological damages from lymphocytic colitis improved six month after he had stopped taking ticlopidine. Chronic diarrhea induced by ticlopidine might be caused by lymphocytic colitis.
AuthorsI Rosa, S Nahon, C Cohen, I Abd Alsamad, J F Fléjou, H Hagege, M Chousterman
JournalAnnales de medecine interne (Ann Med Interne (Paris)) Vol. 150 Issue 5 Pg. 437-9 (Sep 1999) ISSN: 0003-410X [Print] France
Vernacular TitleColite lymphocytaire imputable à la ticlopidine.
PMID10544755 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Fibrinolytic Agents
  • Platelet Aggregation Inhibitors
  • Ticlopidine
Topics
  • Aged
  • Biopsy
  • Chronic Disease
  • Colitis (chemically induced, pathology)
  • Colon (pathology)
  • Diarrhea (chemically induced)
  • Fibrinolytic Agents (adverse effects)
  • Humans
  • Male
  • Platelet Aggregation Inhibitors (adverse effects)
  • Ticlopidine (adverse effects)

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