HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Azithromycin activities against Orientia tsutsugamushi strains isolated in cases of scrub typhus in Northern Thailand.

Abstract
Azithromycin was given to mice and humans infected with strains of Orientia tsutsugamushi from northern Thailand, where drug-resistant scrub typhus occurs. Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively; P > 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed.
AuthorsG Watt, P Kantipong, K Jongsakul, P Watcharapichat, D Phulsuksombati
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 43 Issue 11 Pg. 2817-8 (Nov 1999) ISSN: 0066-4804 [Print] United States
PMID10543774 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Azithromycin
  • Doxycycline
Topics
  • Adult
  • Animals
  • Anti-Bacterial Agents (pharmacology, therapeutic use)
  • Azithromycin (pharmacology, therapeutic use)
  • Doxycycline (therapeutic use)
  • Drug Resistance, Microbial
  • Female
  • Humans
  • Mice
  • Microbial Sensitivity Tests
  • Orientia tsutsugamushi (drug effects)
  • Pregnancy
  • Scrub Typhus (drug therapy, microbiology)
  • Tetracycline Resistance
  • Thailand

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: