Abstract |
Azithromycin was given to mice and humans infected with strains of Orientia tsutsugamushi from northern Thailand, where drug-resistant scrub typhus occurs. Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively; P > 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed.
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Authors | G Watt, P Kantipong, K Jongsakul, P Watcharapichat, D Phulsuksombati |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 43
Issue 11
Pg. 2817-8
(Nov 1999)
ISSN: 0066-4804 [Print] United States |
PMID | 10543774
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Azithromycin
- Doxycycline
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Topics |
- Adult
- Animals
- Anti-Bacterial Agents
(pharmacology, therapeutic use)
- Azithromycin
(pharmacology, therapeutic use)
- Doxycycline
(therapeutic use)
- Drug Resistance, Microbial
- Female
- Humans
- Mice
- Microbial Sensitivity Tests
- Orientia tsutsugamushi
(drug effects)
- Pregnancy
- Scrub Typhus
(drug therapy, microbiology)
- Tetracycline Resistance
- Thailand
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