Hamycin treatment of candidiasis in normal and diabetic rats.

Abstract

Hamycin, a heptaene antifungal antibiotic was compared with amphotericin B in the treatment of established systemic infection with Candida albicans in normal and diabetic rats. In normal rats, orally administered hamycin at 10 mg kg(-1) per day for 7 days reduced Candida colony counts in the kidneys and livers as well as amphotericin B did and was nearly as effective as amphotericin B in a 21-day treatment trial. There was no further reduction in Candida colony counts when normal rats were treated with hamycin at 25 mg kg(-1) twice a day for 7 days. In streptozotocin induced diabetic rats, hamycin at 20 mg kg(-1) per day for either 7 or 21 days compared favourably with amphotericin B in efficacy. Results of the present study suggest that oral hamycin may be useful in the treatment of established disseminated candidiasis in normal as well as diabetic hosts.

• Authors: J N Dhuley
• Journal: FEMS immunology and medical microbiology (FEMS Immunol Med Microbiol) Vol. 26 Issue 2 Pg. 175-80 (Nov 1999) ISSN: 0928-8244 [Print] England
• PMID: 10536305 (Publication Type: Comparative Study, Journal Article, Retracted Publication)

Chemical References

• Antifungal Agents
• Polyenes
• hamycin
• Amphotericin B

Topics

• Administration, Oral
• Amphotericin B (administration & dosage, therapeutic use)
• Animals
• Antifungal Agents (administration & dosage, therapeutic use)
• Candida albicans (growth & development)
• Candidiasis (complications, drug therapy, microbiology)
• Colony Count, Microbial
• Diabetes Mellitus, Experimental (complications)
• Injections, Intraperitoneal
• Kidney (microbiology)
• Liver (microbiology)
• Polyenes (administration & dosage, therapeutic use)
• Rats