[Effects of the Chinese traditional medicines "mao-bushi-saishin-to" and "yokuinin" on the antimycobacterial activity of murine macrophages against Mycobacterium avium complex infection].

We previously examined the effects of two Chinese traditional medicines "Mao-Bushi-Saishin-To" (MBST) and "Yokuinin", on the therapeutic efficacies of a benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex (MAC) infection induced in mice. MBST but not Yokuinin potentiated the therapeutic activity of KRM-1648 against MAC infection. In the present study, we examined the effects of these traditional medicines on some M phi cell functions. First, MBST significantly potentiated M phi anti-MAC antimicrobial activity, while Yokuinin did so to a much lesser extent. Secondly, MBST and Yokuinin each strongly inhibited production of nitric oxide (NO) in MAC-infected M phi s. Thirdly, treatment of M phi s with MBST or Yokuinin caused reductions in the accumulation of IL-10 in culture fluids by MAC-infected M phi s during the first 2-days cultivation. On the other hand, in the separate experiment, treatment of M phi s with these drugs caused no significant change in the accumulation of TGF-beta by MAC-infected M phi s at day 7. These findings suggest that these Chinese traditional medicines, particularly MBST, potentiate M phi anti-MAC antimicrobial activity, however, NO do not appear to be crucial effectors in the anti-MAC activity of MBST- or Yokuinin-treated M phi s. Moreover, MBST- and Yokuinin-mediated down-regulation of the production of IL-10 in MAC-infected M phi s may be related to their potentiating effects on M phi anti-MAC activity.
AuthorsT Shimizu, C Sano, T Akaki, K Ogasawara, K Sato, H Tomioka
JournalKekkaku : [Tuberculosis] (Kekkaku) Vol. 74 Issue 9 Pg. 661-6 (Sep 1999) ISSN: 0022-9776 [Print] JAPAN
PMID10535279 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Drugs, Chinese Herbal
  • Plant Extracts
  • mao-bushi-saishin-to
  • yokuinin
  • Animals
  • Anti-Bacterial Agents (pharmacology, therapeutic use)
  • Anti-Inflammatory Agents (pharmacology, therapeutic use)
  • Drugs, Chinese Herbal (pharmacology, therapeutic use)
  • Female
  • Macrophages (drug effects, immunology, microbiology)
  • Medicine, Chinese Traditional
  • Mice
  • Mice, Inbred BALB C
  • Mycobacterium avium Complex (growth & development)
  • Mycobacterium avium-intracellulare Infection (drug therapy)
  • Plant Extracts (pharmacology, therapeutic use)

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