Inhibitory effect of a gastrin receptor antagonist, CR2945, on 1, 2-dimethylhydrazine-induced colorectal cancer in mice.

Abstract

This study tested the effect of a new gastrin receptor antagonist, CR2945, on colorectal cancer induced by 1,2-dimethylhydrazine (DMH) in mice. 75 CD1 male mice were divided into 3 groups: group 1 received 1 weekly injection of 20 mg/kg of DMH and 2 daily intraperitoneal injections of 0.5 ml of NaCl 0.9% solution for 5 weeks; groups 2 and 3 received the same weekly dose of DMH and 2 daily injections of CR2945 at the respective doses of 2.5 and 7.5 mg/kg for 5 weeks. The animals were sacrificed 25 and 38 weeks after the first injection. No tumours were found at the 25th week. A lower cancer frequency (4%) was observed in treated animals compared to controls (37.4%) at the 38th week (p = 0.002). These data show that CR2945 could prevent chemically induced colon cancer development in mice.

• Authors: M G Fontana, F Donato, V Villanacci, M Ghirardi, D Moneghini, E Di Betta, B Salerni
• Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes (Eur Surg Res) Vol. 31 Issue 5 Pg. 406-11 ( 1999) ISSN: 0014-312X [Print] Switzerland
• PMID: 10529554 (Publication Type: Journal Article)

Chemical References

• CR 2945
• Carcinogens
• Receptors, Cholecystokinin
• Benzodiazepines
• 1,2-Dimethylhydrazine

Topics

• 1,2-Dimethylhydrazine
• Adenocarcinoma (chemically induced, epidemiology, pathology, prevention & control)
• Adenoma (chemically induced, epidemiology, pathology, prevention & control)
• Animals
• Benzodiazepines (pharmacology)
• Carcinogens
• Colorectal Neoplasms (chemically induced, epidemiology, pathology, prevention & control)
• Incidence
• Male
• Mice
• Mice, Inbred Strains
• Receptors, Cholecystokinin (antagonists & inhibitors)