Lower lipoteichoic and teichoic acid CSF concentrations during treatment of pneumococcal meningitis with non-bacteriolytic antibiotics than with ceftriaxone.

Abstract

In the rabbit model of Streptococcus pneumoniae meningitis, treatment with rifabutin, quinupristin-dalfopristin, moxifloxacin and trovafloxacin led to smaller increases of the CSF concentrations of the pro-inflammatory cell wall components lipoteichoic and teichoic acids (LTA and TA) than did treatment with ceftriaxone. Low doses of moxifloxacin were associated with higher LTA and TA concentrations in CSF than were high doses.

• Authors: K Stuertz, H Schmidt, F Trostdorf, H Eiffert, M Mäder, R Nau
• Journal: Scandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 31 Issue 4 Pg. 367-70 ( 1999) ISSN: 0036-5548 [Print] England
• PMID: 10528875 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Aza Compounds
• Cephalosporins
• Fluoroquinolones
• Lipopolysaccharides
• Naphthyridines
• Polysaccharides, Bacterial
• Quinolines
• Teichoic Acids
• Virginiamycin
• quinupristin-dalfopristin
• Rifabutin
• lipoteichoic acid
• Ceftriaxone
• trovafloxacin
• Moxifloxacin

Topics

• Animals
• Anti-Bacterial Agents (administration & dosage)
• Anti-Infective Agents (administration & dosage)
• Aza Compounds
• Ceftriaxone (administration & dosage)
• Cephalosporins (administration & dosage)
• Disease Models, Animal
• Fluoroquinolones
• Immunoenzyme Techniques
• Lipopolysaccharides (cerebrospinal fluid)
• Meningitis, Pneumococcal (cerebrospinal fluid, drug therapy)
• Moxifloxacin
• Naphthyridines (administration & dosage)
• Polysaccharides, Bacterial (cerebrospinal fluid)
• Quinolines
• Rabbits
• Reference Values
• Rifabutin (administration & dosage)
• Teichoic Acids (cerebrospinal fluid)
• Virginiamycin (administration & dosage)