Abstract | AIMS: METHODS: We report here six more cases of malignant epithelial-nonepithelial tumours which, in addition to those reported in the literature, makes a total of 36 presented cases. The pathogenesis of such tumours remains unclear, but it has been claimed that unopposed oestrogenic stimulation due to the agonistic effect of tamoxifen might be involved, as in the case of endometrial carcinomas. Pelvic irradiation has also been incriminated, especiallly in women under 55 years of age. RESULTS: Among 21 endometrial malignant epithelial-nonepithelial tumours associated with tamoxifen, seven occurred in women less than 55 years old. Five of them had previous pelvic irradiation. The data from the literature and from our series suggest that tamoxifen might favour the occurrence of malignant epithelial-nonepithelial tumours in women with breast cancer aged over 55 years, whereas in younger women both pelvic irradiation and tamoxifen might participate.
|
Authors | T Treilleux, H Mignotte, C Clement-Chassagne, P Guastalla, C Bailly |
Journal | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
(Eur J Surg Oncol)
Vol. 25
Issue 5
Pg. 477-82
(Oct 1999)
ISSN: 0748-7983 [Print] England |
PMID | 10527595
(Publication Type: Case Reports, Journal Article, Review)
|
Chemical References |
- Antineoplastic Agents, Hormonal
- Estrogen Receptor Modulators
- Tamoxifen
|
Topics |
- Adult
- Antineoplastic Agents, Hormonal
(adverse effects)
- Breast Neoplasms
(drug therapy)
- Carcinoma
(chemically induced)
- Endometrial Neoplasms
(chemically induced)
- Estrogen Receptor Modulators
(adverse effects)
- Female
- Humans
- Middle Aged
- Tamoxifen
(adverse effects)
- Time Factors
|