[Cathepsin A activity in the vitreous body of patients with absolute glaucoma and intraocular tumors].

Abstract

PURPOSE:

To evaluate cathepsin A activity in the vitreous body of patients with absolute glaucoma and intraocular tumors.

MATERIAL AND METHODS:

The studies were performed on human vitreous body taken from eye balls which were enucleated because of absolute glaucoma (18 eyes) and intraocular tumors (14 eyes). Cathepsin A activity was determined by the ninhydrin method with synthetic substrate (N-Cbz-Phe-Ala) at its optimum pH 5.0.

RESULTS:

Cathepsin A activity in the human vitreous body in absolute glaucoma was twice as high as in intraocular tumors.

CONCLUSION:

Our results suggest that cathepsin A may participate in the pathogenesis of absolute glaucoma and that proteolysis may play a significant role in local destruction of the retina and the optic nerve.

• Authors: I Obuchowska, A Stankiewicz, E Bańkowski
• Journal: Klinika oczna (Klin Oczna) Vol. 101 Issue 3 Pg. 167-8 ( 1999) ISSN: 0023-2157 [Print] Poland
• Vernacular Title: Aktywność katepsyny A w ciele szklistym u chorych z jaskra dokonana i guzami wewnatrzgałkowymi.
• PMID: 10526437 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cathepsins

Topics

• Cathepsins (metabolism)
• Eye Neoplasms (metabolism)
• Glaucoma (metabolism)
• Humans
• Melanoma (metabolism)
• Retrospective Studies
• Vitreous Body (metabolism)