Recognition of deglycosylated larval proteins of Gnathostoma spinigerum by a monoclonal antibody and human gnathostomiasis antiserum.

The study on the recognition of 35S-labelled somatic antigens of Gnathostoma spinigerum advanced third-stage larva (aL3) has revealed that the mAb GN6/24 immunoprecipitated 26- and 24-kDa proteins from the undigested and N-glycosidase F-digested larval extracts, respectively. The recognition of the deglycosylated form of the glycoprotein indicated that the mAb reacted with the peptide epitope on the 26-kDa protein. Human gnathostomiasis antiserum immunoprecipitated most of the N-glycosidase F-digested larval proteins including the deglycosylated 26-kDa protein.
AuthorsP Uparanukraw, T Harnnoi, A Dantrakool, N Morakote, W Chaicumpa
JournalJournal of helminthology (J Helminthol) Vol. 73 Issue 3 Pg. 273-6 (Sep 1999) ISSN: 0022-149X [Print] ENGLAND
PMID10526422 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Antigens, Helminth
  • Helminth Proteins
  • Animals
  • Antibodies, Monoclonal (immunology)
  • Antigens, Helminth (analysis)
  • Eels (parasitology)
  • Glycosylation
  • Gnathostoma (immunology)
  • Helminth Proteins (analysis, immunology)
  • Humans
  • Larva (immunology)
  • Radioimmunoprecipitation Assay
  • Spirurida Infections (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: