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Recognition of deglycosylated larval proteins of Gnathostoma spinigerum by a monoclonal antibody and human gnathostomiasis antiserum.

Abstract
The study on the recognition of 35S-labelled somatic antigens of Gnathostoma spinigerum advanced third-stage larva (aL3) has revealed that the mAb GN6/24 immunoprecipitated 26- and 24-kDa proteins from the undigested and N-glycosidase F-digested larval extracts, respectively. The recognition of the deglycosylated form of the glycoprotein indicated that the mAb reacted with the peptide epitope on the 26-kDa protein. Human gnathostomiasis antiserum immunoprecipitated most of the N-glycosidase F-digested larval proteins including the deglycosylated 26-kDa protein.
AuthorsP Uparanukraw, T Harnnoi, A Dantrakool, N Morakote, W Chaicumpa
JournalJournal of helminthology (J Helminthol) Vol. 73 Issue 3 Pg. 273-6 (Sep 1999) ISSN: 0022-149X [Print] ENGLAND
PMID10526422 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Antigens, Helminth
  • Helminth Proteins
Topics
  • Animals
  • Antibodies, Monoclonal (immunology)
  • Antigens, Helminth (analysis)
  • Eels (parasitology)
  • Glycosylation
  • Gnathostoma (immunology)
  • Helminth Proteins (analysis, immunology)
  • Humans
  • Larva (immunology)
  • Radioimmunoprecipitation Assay
  • Spirurida Infections (immunology)

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