Low-dose cyclosporin for multiple colonic ulcers associated with mixed connective tissue disease.

Abstract

This report describes a patient with multiple colonic ulcers and mixed connective tissue disease. The histological findings of the colonic lesions showed vasculitis with T-cell infiltration, and the peripheral T cells were frequently in the activated phase of the cell cycle. In this patient, low-dose cyclosporin treatment (2.5 mg/kg/day) inhibited the T-cell activation in the peripheral lymphocytes and was very effective in the gastrointestinal disorder, which might be related to T-cell activation. This case suggests the possibility that even low-dose cyclosporin can exert a great influence on peripheral T cells and directly inhibit T-cell activation, thereby improving symptoms related to T-cell activation.

• Authors: N Maeda, S Abe, T Yoshizawa, K Ogawa, I Sekigawa, N Iida, M Eguchi, M Matsumoto, H Hashimoto, S Hirose
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 18 Issue 5 Pg. 410-3 ( 1999) ISSN: 0770-3198 [Print] Germany
• PMID: 10524557 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Cyclosporine

Topics

• Adult
• CD4-CD8 Ratio
• Colonic Diseases (complications, drug therapy, pathology)
• Cyclosporine (administration & dosage)
• Female
• Humans
• Immunosuppressive Agents (administration & dosage)
• Mixed Connective Tissue Disease (complications, immunology)
• T-Lymphocytes (immunology)
• Ulcer (complications, drug therapy, pathology)
• Vasculitis (immunology, pathology)