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The immunopotentiation effects of the bifunctional radiosensitizer KIN-806 in comparison with its analogs KIN-804 and KIN-844.

Abstract
KIN-806 is one of the 2-nitroimidazole derivative hypoxic cell radiosensitizers. Its radiosensitizing effects and the degree of lung metastasis detected were evaluated and compared with its analogs KIN-804 and KIN-844. The immune reactions induced by these radiosensitizers were also analyzed. Female C3H/He mice and SCCVII tumor cells were used. Seventeen days after inoculation of SCCVII tumor cells into the animals, 0.4 g/kg of KIN-806, KIN-804, and KIN-844 was administered to each radiosensitizer group 30 min before 40 Gy was delivered as local irradiation. In each group, KIN-806, KIN-804, and KIN-844 markedly suppressed tumor regrowth in comparison with animals that received irradiation alone. There was no significant difference in the radiosensitizing effects among these three radiosensitizers. A marked suppression of lung metastasis and macrophage/T-lymphocyte infiltration into the tumor were observed only in the KIN-806-administered groups, regardless of the presence or absence of radiation therapy. It therefore appears likely that the lung metastasis suppression was caused by the immune reaction elicited by KIN-806, which is an excellent immunopotentiator as well as an effective radiosensitizer.
AuthorsT Inomata, Y Ogawa, A Nishioka, N Hamada, S Ito, S Kariya, S Yoshida, H Nagasawa, H Hori, S Inayama
JournalOncology reports (Oncol Rep) 1999 Nov-Dec Vol. 6 Issue 6 Pg. 1209-12 ISSN: 1021-335X [Print] GREECE
PMID10523682 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Hydroxamic Acids
  • KIN 806
  • Nitroimidazoles
  • Radiation-Sensitizing Agents
  • 2-nitroimidazole-1-methylacetohydroxamate
Topics
  • Animals
  • Cytotoxicity, Immunologic
  • Female
  • Hydroxamic Acids (administration & dosage)
  • Lung Neoplasms (drug therapy, immunology, radiotherapy, secondary)
  • Mice
  • Mice, Inbred C3H
  • Neoplasms, Experimental (drug therapy, immunology, pathology, radiotherapy)
  • Nitroimidazoles (administration & dosage)
  • Radiation-Sensitizing Agents (administration & dosage)

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