Abstract | PATIENTS AND METHODS: RESULTS: The condition of the patients improved in 75% (primary endpoint). The von Zerssen depression score decreased from 19.8-21.2 (95%-CI) at base-line to 8.1-9.3 at week 6 (p < 0.001). All symptoms were improved at week 3 and further at week 6. The condition improved somewhat slower in patients older than 65 years. The severity of the depression did not appear to have an effect on the outcome. Adverse events were reported by 17% of the patients (gastrointestinal 10%). These were mostly mild or moderate. Tolerance was rated in 89% as satisfactory or better.
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Authors | E Holsboer-Trachsler, C Vanoni |
Journal | Praxis
(Praxis (Bern 1994))
Vol. 88
Issue 37
Pg. 1475-80
(Sep 09 1999)
ISSN: 1661-8157 [Print] Switzerland |
Vernacular Title | Wirksamkeit und Verträglichkeit des Hypericum-Spezialextraktes LI 160 bei depressiven Verstimmungen--eine ambulante Anwendungsbeobachtung. |
PMID | 10522458
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antidepressive Agents
(adverse effects, therapeutic use)
- Depressive Disorder
(drug therapy)
- Female
- Humans
- Hypericum
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Phytotherapy
- Plants, Medicinal
- Treatment Outcome
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