Synthesis of some new heterobicyclic nitrogen systems bearing the 1,2,4-triazine moiety as anti-HIV and anti-cancer drugs, Part II.

Abstract

Some new heterobicyclic nitrogen systems 5-18 and/or thioethers 20, 22 bearing the 1,2,4-triazine moiety have been synthesized via condensation of 3-formylamino-1,2,4-triazine 3 with nitrogen compounds followed by heterocyclization with oxygen reagents. Thioether analogs 20, 22 have been obtained from fusion of compound 19 with 4-chlorothiophenol. The structure of the products have been established by elemental analysis and spectral data. The anti-HIV and anticancer activities of some products have also been investigated where compounds 20a, c and 22b exhibited a moderate activity. The biocidal-structures activity correlation was also studied.

• Authors: R M Abdel-Rahman, J M Morsy, S el-Edfawy, H A Amine
• Journal: Die Pharmazie (Pharmazie) Vol. 54 Issue 9 Pg. 667-71 (Sep 1999) ISSN: 0031-7144 [Print] Germany
• PMID: 10522270 (Publication Type: Journal Article)

Chemical References

• Anti-HIV Agents
• Antineoplastic Agents
• Indicators and Reagents
• Triazines

Topics

• Anti-HIV Agents (chemical synthesis, pharmacology)
• Antineoplastic Agents (chemical synthesis, pharmacology)
• Chemical Phenomena
• Chemistry, Physical
• Drug Screening Assays, Antitumor
• HIV (drug effects)
• Humans
• Indicators and Reagents
• Triazines (chemical synthesis, pharmacology)
• Tumor Cells, Cultured