[Leukopenia associated with butyrophenones. A successful treatment of psychoses with pulsed administration of neuroleptics].

Abstract

In the monotherapeutic treatment of an acute schizophrenic psychoses with butyrophenones (haloperidol and benperidol) we saw immediate leucopenic reactions when the medication was given every day. In literature the risk of butyrophenone-induced blood dyscrasias seems to be underestimated. Therefore we decided to report this single case evaluation. When benperidol (short elimination--half life period) was given every other day ("interval-therapy") the blood cell count of the leucocytes normalized. Furthermore, the amount of psychopathological abnormalities measured by the Brief Psychiatric Rating Scale decreased under this intermittent treatment.

• Authors: M Grube, A Kurzweg
• Journal: Der Nervenarzt (Nervenarzt) Vol. 70 Issue 9 Pg. 838-41 (Sep 1999) ISSN: 0028-2804 [Print] Germany
• Vernacular Title: Leukopenie unter Butyrophenonen. Erfolgreiche Psychosebehandlung durch Neuroleptika-Intervallverabreichung.
• PMID: 10522254 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antipsychotic Agents
• Benperidol
• Haloperidol

Topics

• Antipsychotic Agents (administration & dosage, adverse effects)
• Benperidol (administration & dosage, adverse effects)
• Female
• Haloperidol (administration & dosage, adverse effects)
• Humans
• Leukopenia (chemically induced, prevention & control)
• Middle Aged
• Pulse Therapy, Drug
• Schizophrenia (blood, drug therapy)
• Treatment Outcome