Hb-Alberta or alpha2beta2 (101(G3) Glu replaced by Gly), a new high-oxygen-affinity hemoglobin variant causing erythrocytosis.

Abstract

Hb-Alberta has been found in a 51 year old Caucasian male with erythrocytosis. The substitution in this variant involves the glutamyl residue in position 101(G3) of the beta chain which is replaced by a glycyl residue. Hb-Alberta accounts for about 45% in the heterozygote, and readily forms hybrid tetramers with other hemoglobins. The oxygen affinity of Hb-Alberta is greatly increased, its Bohr effect reduced, and its subunit interaction greatly diminished.

• Authors: M J Mant, M L Salkie, N Cope, F Appling, K Bolch, M Jayalakshmi, M Gravely, J B Wilson, T H Huisman
• Journal: Hemoglobin (Hemoglobin) 1976-1977 Vol. 1 Issue 2 Pg. 183-94 ISSN: 0363-0269 [Print] England
• PMID: 1052180 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amino Acids
• Hemoglobins, Abnormal
• Glutamine
• Lysine
• Oxygen

Topics

• Alberta
• Amino Acids (analysis)
• Electrophoresis, Starch Gel
• Genetic Variation
• Glutamine (blood)
• Hemoglobins, Abnormal (analysis, isolation & purification)
• Humans
• Lysine (blood)
• Male
• Middle Aged
• Oxygen (blood)
• Polycythemia (etiology)