Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: We evaluated 1256 patients, including 23 with aneuploidy (13 with Down syndrome, 10 others). The maternal age was 35.9 +/- 4.6 years (mean +/- SD). At the optimal risk cutoff point for Down syndrome detection (1:190; false-positive rate, 19%), the multiple-marker screening test plus inhibin was superior, detecting 85% of Down syndrome cases, in comparison with 69% when the multiple-marker screening test alone was used and 62% when the other 2 combinations were used. The multiple-marker screening test plus inhibin also detected 60% of the other aneuploidies. CONCLUSIONS: When evaluated prospectively in a high-risk population, the multiple-marker screening test plus inhibin was superior to the traditional multiple-marker screening test and 2 other analyte combinations, with a lower false-positive rate and increased detection of all aneuploidies in a high-risk population.
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Authors | K D Wenstrom, J Owen, D c Chu, L Boots |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 181
Issue 4
Pg. 887-92
(Oct 1999)
ISSN: 0002-9378 [Print] United States |
PMID | 10521748
(Publication Type: Journal Article)
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Chemical References |
- Chorionic Gonadotropin
- Chorionic Gonadotropin, beta Subunit, Human
- alpha-Fetoproteins
- Inhibins
- Estriol
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Topics |
- Amniocentesis
- Aneuploidy
- Chorionic Gonadotropin
(blood)
- Chorionic Gonadotropin, beta Subunit, Human
(blood)
- Dimerization
- Down Syndrome
(diagnosis)
- Estriol
(blood)
- False Positive Reactions
- Female
- Gene Deletion
- Humans
- Inhibins
(blood)
- Pregnancy
- Prenatal Diagnosis
(methods)
- Prospective Studies
- Translocation, Genetic
- Trisomy
- alpha-Fetoproteins
(analysis)
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