[Bone marrow transplantation in the treatment of autoimmune diseases. ISAMAIR Group].

Abstract

EXPERIMENTAL BASIS AND CLINICAL OBSERVATIONS: Remission of an autoimmune disease has been observed in certain patients after bone marrow allograft from a healthy donor. Autoimmune disease in the donor can also be transmitted to an unaffected recipient. These phenomena would be hematopoietic-dependent. BONE MARROW ALLOGRAFTS: Indications for the treatment of refractory autoimmune diseases are exceptional due to the related mortality even in patients without malignant hematologic disease. A NEW THERAPEUTIC CONCEPT: Therapeutic intensification, followed with autologous peripheral stem cell grafts, a procedure with a mortality below 3% in 1997, constitutes a therapeutic alternative in these difficult indication concerning severe refractory autoimmune diseases including: sclerodermia, vasculitis, lupus, inflammatory myositis, autoimmune cyopenia.

• Authors: D Farge, M Breban, L Guillevin, J C Piette, J Cabane, P Cherin, J Cosserat, D Sicard, P Ribaud, J P Marolleau, D Bouscary, X Mariette, C Gisselbrecht, E Gluckman
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 28 Issue 27 Pg. 1488-94 (Sep 18 1999) ISSN: 0755-4982 [Print] France
• Vernacular Title: Les greffes de moelle dans le traitement des maladies auto-immunes. Groupe ISAMAIR.
• PMID: 10520323 (Publication Type: English Abstract, Journal Article, Multicenter Study, Review)

Topics

• Autoimmune Diseases (therapy)
• Bone Marrow Transplantation
• Hematopoietic Stem Cell Transplantation
• Humans
• Transplantation, Autologous
• Transplantation, Homologous