Tissue selective drug delivery utilizing carrier-mediated transport systems.

Abstract

This paper describes some successful examples of a tissue selective drug delivery by utilizing specialized transporter(s) expressed in the targeted tissue cells. These are as follows: (1) oral delivery via H(+)/oligopeptide transporter, rat or human Pept1, in the intestine for beta-lactam antibiotics and a newly synthesized dipeptide, L-dopa-L-phenylalanine; (2) tumor cell specific delivery via the newly discovered H(+)/oligopeptide transporter(s) expressed in human fibrosarcoma cell line HT-1080 for model oligopeptides, glycylsarcosine and carnosine; (3) oral and hepatic delivery via an H(+)/monocarboxylate transporter in the intestine and an organic anion transporter in the liver for HMG-CoA reductase inhibitor, pravastatin; and (4) lung selective delivery via some type of transporter and avoidance of transfer into the brain via P-glycoprotein at the blood-brain barrier for a new quinolone antibacterial, HSR-903.

• Authors: A Tsuji
• Journal: Journal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 62 Issue 1-2 Pg. 239-44 (Nov 01 1999) ISSN: 0168-3659 [Print] Netherlands
• PMID: 10518656 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Carrier Proteins
• Dipeptides
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Lactams
• Peptide Transporter 1
• SLC15A1 protein, human
• Slc15a1 protein, rat
• Symporters
• hydrogen-coupled oligopeptide transporter PepT2
• Pravastatin

Topics

• Animals
• Anti-Bacterial Agents (metabolism)
• Biological Transport
• Brain (metabolism)
• Carrier Proteins (metabolism)
• Dipeptides (metabolism)
• Drug Delivery Systems
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (metabolism)
• Intestinal Mucosa (metabolism)
• Lactams
• Liver (metabolism)
• Organ Specificity
• Peptide Transporter 1
• Pravastatin (metabolism)
• Rats
• Symporters
• Tumor Cells, Cultured
• Xenopus laevis