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Pramipexole, a nonergot dopamine agonist, is effective against rest tremor in intermediate to advanced Parkinson's disease.

Abstract
We evaluated the efficacy of the nonergot dopamine receptor agonist pramipexole in 16 patients with advanced Parkinson's disease and marked rest tremor during an "on" period. The patients were drawn from a larger placebo-controlled, double-blind, randomized trial, which was not originally designed to investigate the effect of pramipexole on tremor. Eleven patients received pramipexole. The first effects were seen with a pramipexole dose of 0.75 mg/d with a reduction of the tremor item A of Unified Parkinson's Disease Rating Scale (UPDRS III, "on" state) by 25% and of rigidity and akinesia by 22%. Under the highest dose, 4.5 mg/d, the tremor score was improved by 61% over baseline (p < 0.0056, Wilcoxon signed rank) and the sum of rigidity and akinesia items by 66% (p < 0.0038, Wilcoxon signed rank). Five patients received placebo and did not improve. Based on this sample of patients, the nonergot dopamine receptor agonist pramipexole appears to have a potent anti-rest tremor action while being effective against akinesia and rigidity.
AuthorsG Künig, O Pogarell, J C Möller, M Delf, W H Oertel
JournalClinical neuropharmacology (Clin Neuropharmacol) 1999 Sep-Oct Vol. 22 Issue 5 Pg. 301-5 ISSN: 0362-5664 [Print] United States
PMID10516884 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Antiparkinson Agents
  • Benzothiazoles
  • Dopamine Agonists
  • Thiazoles
  • Pramipexole
Topics
  • Aged
  • Antiparkinson Agents (therapeutic use)
  • Benzothiazoles
  • Dopamine Agonists (therapeutic use)
  • Humans
  • Middle Aged
  • Parkinson Disease (drug therapy)
  • Pramipexole
  • Severity of Illness Index
  • Thiazoles (therapeutic use)
  • Treatment Outcome
  • Tremor (drug therapy)

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