Graft-versus-myeloma after withdrawal of immunosuppression following allogeneic peripheral stem cell transplantation.

Abstract

There is growing evidence for a graft-versus-myeloma effect following allogeneic stem cell transplantation. We add to this evidence by reporting complete remission achieved by withdrawal of immunosuppression in a patient with multiple myeloma progressing after HLA-identical sibling peripheral stem cell transplantation. De novo chronic graft-versus-host disease coincided with the anti-myeloma effect and responded to treatment. The patient remains in complete remission 3 years after transplant.

• Authors: J Libura, T Hoffmann, J Passweg, M Gregor, G Favre, A Tichelli, A Gratwohl
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 24 Issue 8 Pg. 925-7 (Oct 1999) ISSN: 0268-3369 [Print] England
• PMID: 10516707 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Female
• Graft vs Tumor Effect
• Hematopoietic Stem Cell Transplantation
• Humans
• Immunosuppression Therapy
• Multiple Myeloma (immunology, therapy)
• Transplantation, Homologous