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[Effect of mildronate on life quality of patients with chronic heart failure].

AbstractAIM:
To study quality of life (QL) of patients with chronic heart failure (CHF) and QL changes resultant from mildronate therapy.
MATERIALS AND METHODS:
QL was studied in 30 IHD patients with CHF of NYHA class II-IV, ejection fraction > 45%; 40 IHD patients without CHF and 30 healthy subjects. CHF patients were treated for 30 days with oral mildronate (250 mg 4 times a day). QL was assessed according to the method SF-36 Health Status Survey.
RESULTS:
QL in CHF patients is much lower than that of the controls. Objective severity of the disease and subjective satisfaction with life do not always coincide. Mildronate in a dose 1 g/day per os may be beneficial for LQ of CHF patients.
CONCLUSION:
It is thought desirable to include QL in analysis of efficiency of managing patients with CHF. SF-36 is a tool able to follow up changes in QL of CHF patients within a short-term treatment period.
AuthorsA O Nedoshivin, N N Petrova, A E Kutuzova, N B Perepech
JournalTerapevticheskii arkhiv (Ter Arkh) Vol. 71 Issue 8 Pg. 10-2 ( 1999) ISSN: 0040-3660 [Print] Russia (Federation)
Vernacular TitleKachestvo zhizni bol'nykh s khronicheskoĭ serdechnoĭ nedostatochnost'iu. Effekt lecheniia mildronatom.
PMID10515026 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Cardiovascular Agents
  • Methylhydrazines
  • 3-(2,2,2-trimethylhydrazine)propionate
Topics
  • Administration, Oral
  • Adult
  • Cardiovascular Agents (administration & dosage, therapeutic use)
  • Chronic Disease
  • Female
  • Heart Failure (drug therapy, physiopathology, psychology)
  • Humans
  • Male
  • Methylhydrazines (administration & dosage, therapeutic use)
  • Middle Aged
  • Myocardial Ischemia (drug therapy, physiopathology, psychology)
  • Patient Satisfaction
  • Quality of Life
  • Stroke Volume (drug effects)
  • Treatment Outcome

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