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Repression of acyl-CoA:cholesterol acyltransferase by a traditional herbal medicine (Kampo medicine), Ogi-Keishi-Gomotsu-To-Ka-Kojin.

Abstract
Ogi-Keishi-Gomotsu-To-Ka-Kojin (OKGK) is a traditional herbal medicine (Kampo medicine) which has been found to ameliorate hypercholesterolemia and hypertriglyceridemia in rats and rabbits. In the present study, the effect of OKGK on acyl-CoA:cholesterol acyltransferase (ACAT) was studied in order to elucidate the mechanism of its antihypercholesterolemic action. Oral administration of OKGK to rats fed a cholesterol-enriched diet for 4 weeks markedly repressed the increase in ACAT activity in the small intestine. In contrast, OKGK did not influence hepatic ACAT activity. These results indicate that OKGK selectively inhibits ACAT activity in the small intestine relative to that in the liver, resulting in a reduction of cholesterol absorption, followed by a decrease in serum cholesterol.
AuthorsC Z Wu, M Inoue, Y Ogihara
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 22 Issue 9 Pg. 994-6 (Sep 1999) ISSN: 0918-6158 [Print] Japan
PMID10513630 (Publication Type: Journal Article)
Chemical References
  • Drugs, Chinese Herbal
  • ogi-keishi-gomotsu-to-ka-kojin
  • Sterol O-Acyltransferase
Topics
  • Adrenal Glands (drug effects)
  • Animals
  • Drugs, Chinese Herbal (pharmacology, therapeutic use)
  • Enzyme Repression
  • Hypercholesterolemia (drug therapy)
  • Intestine, Small (drug effects, enzymology)
  • Liver (drug effects, enzymology)
  • Male
  • Medicine, Kampo
  • Phytotherapy
  • Rats
  • Rats, Sprague-Dawley
  • Sterol O-Acyltransferase (antagonists & inhibitors)

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