HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Linear IgA bullous dermatosis of childhood: a long-term study.

AbstractBACKGROUND:
Linear IgA bullous dermatosis (LAD) of childhood is a rare acquired subepidermal blistering disease of young children. Most of the studies were reported from the USA and European countries.
METHOD:
Twelve cases of Thai patients diagnosed as LAD of childhood were analyzed concerning clinical, histopathological, immunopathological findings including treatment responses and courses compared with those of Caucasians.
RESULT:
The mean age of onset was 5.1 years. The areas of common involvement were the perioral region, lower abdomen, perineum, buttock, inner thighs and extremities. Histopathology in half of the cases showed features of dermatitis herpetiformis or bullous pemphigoid. All patients had positive linear IgA band at the basement membrane zone (BMZ) by direct immunofluorescence. Only one patient had positive circulating anti BMZ antibody at the titer of 1:10. Most patients responded well to dapsone. The mean duration before remission was 1.9 years.
CONCLUSION:
Our study in Thai patients with LAD of childhood produced data similar to previous studies carried out in the Caucasian nations.
AuthorsK Kulthanan, R Akaraphanth, T Piamphongsant, P Kullavanijaya
JournalJournal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 82 Issue 7 Pg. 707-12 (Jul 1999) ISSN: 0125-2208 [Print] Thailand
PMID10511773 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Immunoglobulin A
  • Dapsone
Topics
  • Adolescent
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
  • Child
  • Child, Preschool
  • Dapsone (administration & dosage)
  • Evaluation Studies as Topic
  • Female
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • Immunoglobulin A (analysis)
  • Male
  • Prognosis
  • Severity of Illness Index
  • Skin Diseases, Vesiculobullous (drug therapy, immunology, pathology)
  • Thailand

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: