Abstract | BACKGROUND AND OBJECTIVE:
Desmopressin ( DDAVP) may shorten bleeding time in patients with disorders of platelet function, but its mechanism of action in these conditions is still a matter of debate. In particular, contrasting results have been obtained concerning the ability of DDAVP to interact with platelets and to activate them directly. To gain further information on the DDAVP-platelet interaction, we studied the in vitro and ex vivo effects of DDAVP on platelet function. DESIGN AND METHODS: Platelet responses to DDAVP both as a single agent and in conjunction with agonists of platelet activation were investigated. For in vitro experiments platelets were obtained from healthy adult volunteers, while the ex vivo effects of DDAVP were studied in 12 patients with a bleeding disorder receiving a test dose of this drug. RESULTS: INTERPRETATION AND CONCLUSIONS: Our in vitro experiments indicate that DDAVP interacts directly with platelets and facilitates their activation via other agonists. In vivo results suggest that this effect occurs and is clinically relevant in patients with platelet dysfunction responding to DDAVP with a shortening of bleeding time.
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Authors | C L Balduini, P Noris, S Belletti, P Spedini, G Gamba |
Journal | Haematologica
(Haematologica)
Vol. 84
Issue 10
Pg. 891-6
(Oct 1999)
ISSN: 0390-6078 [Print] Italy |
PMID | 10509036
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- Adenosine Diphosphate
- Collagen
- Deamino Arginine Vasopressin
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Topics |
- Adenosine Diphosphate
(pharmacology)
- Antigens, CD
(analysis)
- Bleeding Time
- Blood Platelets
(drug effects, physiology)
- Collagen
(pharmacology)
- Deamino Arginine Vasopressin
(administration & dosage, pharmacology)
- Hemorrhage
(drug therapy, metabolism)
- Humans
- Platelet Activation
(drug effects, immunology)
- Platelet Aggregation
(drug effects)
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