Type VI collagen immunoreactivity in skeinoid fibers in small intestinal stromal tumors.

Abstract

By immunoperoxidase analysis for types I to VI collagen, elastin, cytoskeletal components and some glycoproteins, we found type VI collagen immunoreactivity in amorphous eosinophilic deposits (skeinoid fibers) in three small intestinal stromal tumors. Negative results were obtained for types I, II, III, IV and V collagen, elastin, laminin, ubiquitin, intracellular filaments such as actin, desmin, vimentin, calponin and caldesmon, and glycoprotein such as lysozyme, factor XIIIa, beta2-microglobulin, alpha1-antitrypsin and alpha1-antichymotrypsin. In two lesions, the periodic acid-Schiff-positive skeinoid fibers were also focally labeled for amyloid P component.

• Authors: Y Tsutsumi, K Tazawa, M Shibuya
• Journal: Pathology international (Pathol Int) Vol. 49 Issue 9 Pg. 836-9 (Sep 1999) ISSN: 1320-5463 [Print] Australia
• PMID: 10504558 (Publication Type: Letter)

Chemical References

• Biomarkers
• Serum Amyloid P-Component
• Collagen

Topics

• Adult
• Biomarkers (analysis)
• Collagen (analysis, metabolism)
• Duodenal Neoplasms (chemistry, metabolism, pathology)
• Female
• Humans
• Immunoenzyme Techniques
• Inclusion Bodies (chemistry, metabolism, ultrastructure)
• Jejunal Neoplasms (chemistry, metabolism, pathology)
• Middle Aged
• Serum Amyloid P-Component (analysis)
• Stromal Cells (chemistry, metabolism, pathology)