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Expression and clinical significance of apolipoprotein D in male breast cancer and gynaecomastia.

AbstractBACKGROUND:
Apolipoprotein D (Apo D) is a protein component of the human plasma lipid transport system which is present in benign and malignant human breast tissues. This study analysed the expression of Apo D in men with gynaecomastia or breast cancer, and evaluated its use as a prognostic marker in breast cancer.
METHODS:
Immunohistochemical expression of Apo D was examined in specimens from 15 men with gynaecomastia, two with in situ breast carcinoma and 68 with invasive male breast cancer. Median follow-up in patients with breast cancer was 44 months.
RESULTS:
All gynaecomastia specimens, both in situ carcinomas and 57 invasive carcinomas (84 per cent) stained positively for Apo D. Apo D values were significantly correlated with axillary node involvement and histological grade of the tumours. In men with breast cancer univariate analysis showed a statistical association between node status and Apo D content with relapse-free survival (P < 0.001) and overall survival (P < 0.05). Cox multivariate analysis showed that Apo D was a significant indicator of relapse-free survival (P = 0. 0089), but node status was the strongest factor able to predict both relapse-free (P = 0.0336) and overall (P = 0.0346) survival.
CONCLUSION:
Apo D was expressed in gynaecomastia and a high percentage of male breast carcinomas. There was a positive association of Apo D content in male breast tumours with favourable outcome. Apo D expression was a significant independent indicator of relapse-free survival in male breast cancer.
AuthorsC Serra Díaz, F Vizoso, M L Lamelas, J C Rodríguez, L O González, A Baltasar, J Medrano
JournalThe British journal of surgery (Br J Surg) Vol. 86 Issue 9 Pg. 1190-7 (Sep 1999) ISSN: 0007-1323 [Print] England
PMID10504376 (Publication Type: Journal Article, Multicenter Study)
Chemical References
  • Apolipoproteins
  • Apolipoproteins D
  • Biomarkers
Topics
  • Adolescent
  • Adult
  • Aged
  • Apolipoproteins (metabolism)
  • Apolipoproteins D
  • Biomarkers
  • Breast Neoplasms, Male (metabolism)
  • Carcinoma in Situ (metabolism)
  • Disease-Free Survival
  • Gynecomastia (metabolism)
  • Humans
  • Immunohistochemistry
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Prognosis
  • Survival Analysis

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