Abstract | BACKGROUND: METHODS: RESULTS: All gynaecomastia specimens, both in situ carcinomas and 57 invasive carcinomas (84 per cent) stained positively for Apo D. Apo D values were significantly correlated with axillary node involvement and histological grade of the tumours. In men with breast cancer univariate analysis showed a statistical association between node status and Apo D content with relapse-free survival (P < 0.001) and overall survival (P < 0.05). Cox multivariate analysis showed that Apo D was a significant indicator of relapse-free survival (P = 0. 0089), but node status was the strongest factor able to predict both relapse-free (P = 0.0336) and overall (P = 0.0346) survival. CONCLUSION:
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Authors | C Serra Díaz, F Vizoso, M L Lamelas, J C Rodríguez, L O González, A Baltasar, J Medrano |
Journal | The British journal of surgery
(Br J Surg)
Vol. 86
Issue 9
Pg. 1190-7
(Sep 1999)
ISSN: 0007-1323 [Print] England |
PMID | 10504376
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
- Apolipoproteins
- Apolipoproteins D
- Biomarkers
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Topics |
- Adolescent
- Adult
- Aged
- Apolipoproteins
(metabolism)
- Apolipoproteins D
- Biomarkers
- Breast Neoplasms, Male
(metabolism)
- Carcinoma in Situ
(metabolism)
- Disease-Free Survival
- Gynecomastia
(metabolism)
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Male
- Middle Aged
- Multivariate Analysis
- Prognosis
- Survival Analysis
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