Abstract | BACKGROUND/AIMS: METHODS: A randomised, double blind, crossover clinical trial in which subjects were randomised to receive either hyaluronan or saline, applied as one or two drops to the eye, three or four times a day or as required. After 28 days' treatment, subjects crossed over to the other study medication for a further 28 days' treatment. RESULTS: 70 subjects were included in the analyses of efficacy and significant improvements in Schirmer's score (p=0.0006) and rose bengal staining score (p=0.0001) were observed during treatment with hyaluronan. In a subjective assessment of the effectiveness of two treatments, a majority of subjects felt that hyaluronan was more effective than saline in alleviating the symptoms of burning and grittiness (p<0.001). No adverse events attributable to hyaluronan treatment were reported. CONCLUSION:
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Authors | P I Condon, C G McEwen, M Wright, G Mackintosh, R J Prescott, C McDonald |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 83
Issue 10
Pg. 1121-4
(Oct 1999)
ISSN: 0007-1161 [Print] England |
PMID | 10502570
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Ophthalmic Solutions
- Sodium Chloride
- Hyaluronic Acid
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Topics |
- Adult
- Aged
- Cross-Over Studies
- Double-Blind Method
- Dry Eye Syndromes
(drug therapy)
- Female
- Humans
- Hyaluronic Acid
(therapeutic use)
- Male
- Middle Aged
- Ophthalmic Solutions
- Patient Satisfaction
- Sodium Chloride
(therapeutic use)
- Treatment Outcome
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