Abstract | BACKGROUND: Three people with clinical manifestations of acute renal failure with neurological involvement of unknown cause were admitted to a hospital in Mumbai, India. We describe clinical presentations and investigations of the cause. METHODS: We analysed case reports and laboratory findings for the patients (age 37-43 years, two men, one woman) that were provided by the clinicians in charge. Serum and cerebrospinal fluid were tested for viral cause by IgM ELISA to Japanese encephalitis, West Nile fever, dengue, and measles. Samples were inoculated in vero-cell culture for virus isolation. The virus isolates were confirmed with indirect immunofluoresence with antimeasles immune sera and mouse monoclonal antibodies to measles HA and F proteins and with neutralisation tests using antimeasles immune sera. FINDINGS: INTERPRETATION: Unusual manifestations of acute renal failure with neurological involvement associated with measles virus in adults presenting without rash was confirmed. Our findings may affect the development of measles-elimination programmes.
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Authors | N S Wairagkar, B V Gandhi, S M Katrak, N J Shaikh, P R Parikh, N H Wadia, D A Gadkari |
Journal | Lancet (London, England)
(Lancet)
Vol. 354
Issue 9183
Pg. 992-5
(Sep 18 1999)
ISSN: 0140-6736 [Print] England |
PMID | 10501362
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Acute Kidney Injury
(epidemiology, virology)
- Adult
- Female
- Humans
- India
(epidemiology)
- Male
- Measles
(diagnosis, epidemiology)
- Measles virus
(isolation & purification)
- Nervous System Diseases
(diagnosis, virology)
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