HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: alpha-bungarotoxin and nicotine binding in the thalamus.

Abstract
Neuronal nicotinic receptors have been implicated in schizophrenia on the basis of the high incidence of tobacco smoking in patients, abnormalities in cytisine and alpha-bungarotoxin (alphaBGT) binding in the hippocampus, and linkage between auditory P50 deficits and the region of chromosome 15 coding the alpha7 subunit. In another disease associated with psychosis, dementia with Lewy bodies (DLB), in which visual hallucinations predominate, reductions in nicotine binding have been identified in various cortical and subcortical regions. We investigated both alphaBGT and nicotine binding autoradiographically in different thalamic nuclei in autopsy brain tissue from patients with schizophrenia and DLB. AlphaBGT binding in the reticular nucleus was moderately reduced (25%) in schizophrenia and more extensively reduced (50%) in DLB. There were no significant alterations in nicotine binding in schizophrenia, and in DLB, a trend towards moderate reductions in most nuclei reached significance in the lateral dorsal nucleus. It is concluded that widespread abnormalities of thalamic nicotine are not implicated in schizophrenia or DLB, but that reticular alphaBGT binding may be involved to a lesser and greater extent in the pathophysiology or psychopathology of both disorders.
AuthorsJ Court, D Spurden, S Lloyd, I McKeith, C Ballard, N Cairns, R Kerwin, R Perry, E Perry
JournalJournal of neurochemistry (J Neurochem) Vol. 73 Issue 4 Pg. 1590-7 (Oct 1999) ISSN: 0022-3042 [Print] UNITED STATES
PMID10501205 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Bungarotoxins
  • Receptors, Nicotinic
  • Nicotine
Topics
  • Aged
  • Aged, 80 and over
  • Bungarotoxins (pharmacokinetics)
  • Dementia (metabolism, pathology)
  • Humans
  • Lewy Bodies (pathology)
  • Middle Aged
  • Neurons (metabolism, pathology)
  • Nicotine (pharmacokinetics)
  • Receptors, Nicotinic (metabolism)
  • Reference Values
  • Schizophrenia (metabolism, pathology)
  • Thalamus (metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: